From Pierre-Elliot Trudeau (Dorval) International Airport:

1. Take Ramp (LEFT) onto Highway-520 [Autoroute de la Côte-SR-Liesse]
    towards AUTOROUTE-20 / Montréal / Centre-Ville / Toronto
2. At roundabout, take the THIRD exit onto Local road(s)
3. Road name changes to Boulevard Montréal-Toronto
    [Montreal-Toronto Hwy]
4. Take Ramp (LEFT) onto Highway-20 towards Montréal / Centre-Ville
5. Road name changes to AUT-720 (Autoroute Ville-Marie)
6. At exit 3, keep RIGHT onto Ramp towards Guy
7. Turn RIGHT onto Boulevard René-Lévesque West
8. Turn LEFT onto University
9. Turn RIGHT onto Sherbrooke West
10. We are at 550 Sherbrooke West

From Ottawa:

1. Take Highway-417 towards Montreal
2. Entering province of Quebec Road name changes to TC-40
3. At exit 66-S, take Ramp (LEFT) onto Highway-15 (Autoroute Décarie)
    towards Highway-15 (AUT-15 / AUT-10 / Aut. Décarie / Sherbrooke /
    Pont Champlain)
4. At exit 63-E, take Ramp (LEFT) onto Highway-20 (AUT-720) towards
    Aut. Ville-Marie / Centre-Ville
5. At exit 3, keep RIGHT onto Ramp towards Guy
6. Turn RIGHT onto Boulevard René-Lévesque West
7. Turn LEFT onto University
8. Turn RIGHT onto Sherbrooke West
9. We are at 550 Sherbrooke West

From Boston:

1. Take highway I-93 North
2. Entering Vermont, take Ramp (RIGHT) onto I-91 North
3. Entering Quebec, road changes name to AUT-55
4. At Exit 34-O, take Ramp (LEFT) onto Highway-10 towards Montreal
5. At Exit 58, keep RIGHT onto Ramp towards AUT-10 / HWY-10 / Montreal /     Downtown
6. Entering the city, name changes to University
7. Turn RIGHT onto Sherbrooke West
8. We are at 550 Sherbrooke West